Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat
Author
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-05-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The Spontaneously Diabetic Torii (SDT) rat, a nonobese type 2 diabetes model, develops severe diabetic retinopathy as result of chronic severe hyperglycemia.
Although existing diabetes animal models also develop ocular complications, severe retinal lesions frequently observed in human diabetes patients such as preretinal neovascularization or retinal detachment are not found.
Distinctive features in SDT rat are hypermature cataract, tractional retinal detachment with fibrous proliferation, and massive hemorrhaging in the anterior chamber.
These pathophysiological changes are caused by sustained hyperglycemic condition and subsequent increased expression of vascular endothelial growth factor (VEGF) in retina, iris, and ciliary body.
Although some differences in diabetic retinopathy exist between SDT rats and humans (e.g., a low incidence of neovascular formation and poor development of nonperfused area are found in this animal), SDT rat will be a useful model in studies of the pathogenesis and treatment of diabetic retinopathy.
American Psychological Association (APA)
Sasase, Tomohiko. 2010. Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat. Journal of Ophthalmology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485337
Modern Language Association (MLA)
Sasase, Tomohiko. Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat. Journal of Ophthalmology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-485337
American Medical Association (AMA)
Sasase, Tomohiko. Pathophysiological Characteristics of Diabetic Ocular Complications in Spontaneously Diabetic Torii Rat. Journal of Ophthalmology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485337
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485337