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The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease
Joint Authors
Lenar, David P.
Quinn, Joseph F.
Anderson, Valerie C.
Rooney, William D.
Source
Cardiovascular Psychiatry and Neurology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer's disease (AD) is the most common form of dementia in the elderly.
Although traditionally considered a disease of neurofibrillary tangles and amyloid plaques, structural and functional changes in the microvessels may contribute directly to the pathogenesis of the disease.
Since vascular dysfunction often precedes cognitive impairment, understanding the role of the blood-brain barrier (BBB) in AD may be key to rational treatment of the disease.
We propose that water regulation, a critical function of the BBB, is disturbed in AD and results in abnormal permeability and rates of water exchange across the vessel walls.
In this paper, we describe some of the pathological events that may disturb microvascular water exchange in AD and examine the potential of a relatively new imaging technique, dynamic contrast-enhanced MRI, to quantify water exchange on a cellular level and thus serve as a probe of BBB integrity in AD.
American Psychological Association (APA)
Anderson, Valerie C.& Lenar, David P.& Quinn, Joseph F.& Rooney, William D.. 2011. The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease. Cardiovascular Psychiatry and Neurology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485353
Modern Language Association (MLA)
Anderson, Valerie C.…[et al.]. The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease. Cardiovascular Psychiatry and Neurology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485353
American Medical Association (AMA)
Anderson, Valerie C.& Lenar, David P.& Quinn, Joseph F.& Rooney, William D.. The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease. Cardiovascular Psychiatry and Neurology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485353
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485353