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Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I
Joint Authors
Morimura, Shigeru
Takahashi, Kazuhide
Source
International Journal of Cell Biology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Cell migration is considered necessary for the invasion that accompanies the directional formation of the cellular protrusions termed lamellipodia.
In invasive breast cancer MDA-MB-231 cells, lamellipodia formation is preceded by translocation of the actin cytoskeletal regulatory protein WAVE2 to the leading edge.
WAVE2 translocation and lamellipodia formation require many signaling molecules, including PI3K, Rac1, Pak1, IRSp53, stathmin, and EB1, but whether these molecules are necessary for invasion remains unclear.
In noninvasive breast cancer MCF7 cells, no lamellipodia were induced by IGF-I, whereas in MDA-MB-231 cells, Rac1, stathmin, and EB1 were overexpressed.
Depletion of Rac1 or stathmin by small interfering RNA abrogated the IGF-I-induced invasion of MDA-MB-231 cells; however, depletion of EB1 did not, indicating the necessity of Rac1 and stathmin but not EB1 for invasion.
The signaling pathway leading to cell invasion may not be identical but shares some common molecules, leading to cell migration through lamellipodia formation.
American Psychological Association (APA)
Morimura, Shigeru& Takahashi, Kazuhide. 2011. Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I. International Journal of Cell Biology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485361
Modern Language Association (MLA)
Morimura, Shigeru& Takahashi, Kazuhide. Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I. International Journal of Cell Biology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485361
American Medical Association (AMA)
Morimura, Shigeru& Takahashi, Kazuhide. Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I. International Journal of Cell Biology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485361
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485361