The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma
Joint Authors
Bukholm, Geir
Aamodt, Rolf
Bukholm, Ida Rashida Khan
Bakka, Arne
Andersen, Solveig Norheim
Bondi, Johan
Source
Gastroenterology Research and Practice
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-08-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The E-cadherin-catenin complex provides cell-cell adhesion.
In order for a carcinoma to metastasize, cancer cells must let go of their hold of neighboring cells in the primary tumor.
The presence of components of the E-cadherin-catenin complex in 246 rectal adenocarcinomas was examined by immunohistochemistry and compared to their presence in 219 colon carcinomas.
The expression data were correlated to clinical information from the patients' records.
There were statistically significant differences in protein expression between the rectal and the colon carcinomas regarding membranous β-catenin, γ-catenin, p120-catenin, and E-cadherin, as well as nuclear β-catenin.
In the rectal carcinomas, there was a significant inverse association between the expression of p120-catenin in cell membranes of the primary tumors and the occurrence of local recurrence, while membranous protein expression of β-catenin was inversely related to distant metastases.
American Psychological Association (APA)
Aamodt, Rolf& Bondi, Johan& Andersen, Solveig Norheim& Bakka, Arne& Bukholm, Geir& Bukholm, Ida Rashida Khan. 2010. The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma. Gastroenterology Research and Practice،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485373
Modern Language Association (MLA)
Aamodt, Rolf…[et al.]. The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma. Gastroenterology Research and Practice No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-485373
American Medical Association (AMA)
Aamodt, Rolf& Bondi, Johan& Andersen, Solveig Norheim& Bakka, Arne& Bukholm, Geir& Bukholm, Ida Rashida Khan. The Prognostic Impact of Protein Expression of E-Cadherin-Catenin Complexes Differs between Rectal and Colon Carcinoma. Gastroenterology Research and Practice. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485373
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485373