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Cerebrovascular Accidents Associated with Sorafenib in Hepatocellular Carcinoma
Joint Authors
Saif, Muhammad W.
Peccerillo, Jennifer
Isufi, Iris
Syrigos, Kostas N.
Source
Gastroenterology Research and Practice
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-30
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Sorafenib is an oral angiogenetic multikinase inhibitor approved in the treatment of renal and hepatocellular carcinoma.
Bleeding and venous thrombotic events have been described with angiogenetic agents but cerebrovascular accidents are rarely reported.
We report two cases of patients with hepatocellular carcinoma who developed a cerebrovascular accident while on sorafenib.
Neither patient had any risk factors for the cerebrovascular events apart from gender and age in the second patient.
Laboratory data were noncontributory.
The head CT scan did not reveal acute abnormalities.
No hemodynamically significant stenosis was visible in the carotid ultrasound, and the echocardiogram showed normal size of the heart chambers and normal systolic function of the left ventricle.
Sorafenib was discontinued in both cases.
Physicians should monitor patients receiving sorafenib for neurologic symptoms, and in the absence of other etiology, prompt discontinuation of this drug should be considered.
American Psychological Association (APA)
Saif, Muhammad W.& Isufi, Iris& Peccerillo, Jennifer& Syrigos, Kostas N.. 2011. Cerebrovascular Accidents Associated with Sorafenib in Hepatocellular Carcinoma. Gastroenterology Research and Practice،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-485378
Modern Language Association (MLA)
Saif, Muhammad W.…[et al.]. Cerebrovascular Accidents Associated with Sorafenib in Hepatocellular Carcinoma. Gastroenterology Research and Practice No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-485378
American Medical Association (AMA)
Saif, Muhammad W.& Isufi, Iris& Peccerillo, Jennifer& Syrigos, Kostas N.. Cerebrovascular Accidents Associated with Sorafenib in Hepatocellular Carcinoma. Gastroenterology Research and Practice. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-485378
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485378