The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease
Joint Authors
Loreto, Carla
Caltabiano, Rosario
Anzalone, Rita
Vespasiani, Giuseppe
Castorina, Sergio
Djinovic, Rados
Giunta, Salvatore
La Rocca, Giampiero
Ralph, David J.
Cellek, Selim
Musumeci, Giuseppe
Basic, Dragoslav
Sansalone, Salvatore
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-13
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Peyronie’s disease (PD) is characterized with formation of fibrous plaques which result in penile deformity, pain, and erectile dysfunction.
The aim of this study was to investigate the activation of the intrinsic apoptotic pathway in plaques from PD patients.
Tunica albuginea from either PD or control patients was assessed for the expression of bax, bcl-2 and caspases 9 and 3 using immunohistochemistry and by measurement of apoptotic cells using TUNEL assay.
Bax overexpression was observed in metaplastic bone tissue, in fibroblasts, and in myofibroblast of plaques from PD patients.
Little or no bcl-2 immunostaining was detected in samples from either patients or controls.
Caspase 3 immunostaining was very strong in fibrous tissue, in metaplasic bone osteocytes, and in primary ossification center osteoblasts.
Moderate caspase 9 immunostaining was seen in fibrous cells plaques and in osteocytes and osteoblasts of primary ossification centers from PD patients.
Control samples were negative for caspase 9 immunostaining.
In PD patients the TUNEL immunoassay showed intense immunostaining of fibroblasts and myofibroblasts, the absence of apoptotic cells in metaplasic bone tissue and on the border between fibrous and metaplastic bone tissue.
Apoptosis occurs in stabilized PD plaques and is partly induced by the intrinsic pathway.
American Psychological Association (APA)
Loreto, Carla& La Rocca, Giampiero& Anzalone, Rita& Caltabiano, Rosario& Vespasiani, Giuseppe& Castorina, Sergio…[et al.]. 2014. The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-485386
Modern Language Association (MLA)
Loreto, Carla…[et al.]. The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-485386
American Medical Association (AMA)
Loreto, Carla& La Rocca, Giampiero& Anzalone, Rita& Caltabiano, Rosario& Vespasiani, Giuseppe& Castorina, Sergio…[et al.]. The Role of Intrinsic Pathway in Apoptosis Activation and Progression in Peyronie’s Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-485386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485386