MRI-Guided Focused Ultrasound as a New Method of Drug Delivery
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-12
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Ultrasound-mediated drug delivery under the guidance of an imaging modality can improve drug disposition and achieve site-specific drug delivery.
The term focal drug delivery has been introduced to describe the focal targeting of drugs in tissues with the help of imaging and focused ultrasound.
Focal drug delivery aims to improve the therapeutic profile of drugs by improving their specificity and their permeation in defined areas.
Focused-ultrasound- (FUS-) mediated drug delivery has been applied with various molecules to improve their local distribution in tissues.
FUS is applied with the aid of microbubbles to enhance the permeability of bioactive molecules across BBB and improve drug distribution in the brain.
Recently, FUS has been utilised in combination with MRI-labelled liposomes that respond to temperature increase.
This strategy aims to “activate” nanoparticles to release their cargo locally when triggered by hyperthermia induced by FUS.
MRI-guided FUS drug delivery provides the opportunity to improve drug bioavailability locally and therefore improve the therapeutic profiles of drugs.
This drug delivery strategy can be directly translated to clinic as MRg FUS is a promising clinically therapeutic approach.
However, more basic research is required to understand the physiological mechanism of FUS-enhanced drug delivery.
American Psychological Association (APA)
Thanou, M.& Gedroyc, W.. 2013. MRI-Guided Focused Ultrasound as a New Method of Drug Delivery. Journal of Drug Delivery،Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485391
Modern Language Association (MLA)
Thanou, M.& Gedroyc, W.. MRI-Guided Focused Ultrasound as a New Method of Drug Delivery. Journal of Drug Delivery No. 2013 (2013), pp.1-12.
https://search.emarefa.net/detail/BIM-485391
American Medical Association (AMA)
Thanou, M.& Gedroyc, W.. MRI-Guided Focused Ultrasound as a New Method of Drug Delivery. Journal of Drug Delivery. 2013. Vol. 2013, no. 2013, pp.1-12.
https://search.emarefa.net/detail/BIM-485391
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485391