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True Lies : The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair
Joint Authors
Le May, Nicolas
Coin, Frédéric
Egly, Jean-Marc
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Nucleotide excision repair (NER) is a major DNA repair pathway in eukaryotic cells.
NER removes structurally diverse lesions such as pyrimidine dimers, arising upon UV irradiation or bulky chemical adducts, arising upon exposure to carcinogens and some chemotherapeutic drugs.
NER defects lead to three genetic disorders that result in predisposition to cancers, accelerated aging, neurological and developmental defects.
During NER, more than 30 polypeptides cooperate to recognize, incise, and excise a damaged oligonucleotide from the genomic DNA.
Recent papers reveal an additional and unexpected role for the NER factors.
In the absence of a genotoxic attack, the promoters of RNA polymerases I- and II-dependent genes recruit XPA, XPC, XPG, and XPF to initiate gene expression.
A model that includes the growth arrest and DNA damage 45α protein (Gadd45α) and the NER factors, in order to maintain the promoter of active genes under a hypomethylated state, has been proposed but remains controversial.
This paper focuses on the double life of the NER factors in DNA repair and transcription and describes the possible roles of these factors in the RNA synthesis process.
American Psychological Association (APA)
Le May, Nicolas& Egly, Jean-Marc& Coin, Frédéric. 2010. True Lies : The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair. Journal of Nucleic Acids،Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-485402
Modern Language Association (MLA)
Le May, Nicolas…[et al.]. True Lies : The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair. Journal of Nucleic Acids No. 2010 (2010), pp.1-10.
https://search.emarefa.net/detail/BIM-485402
American Medical Association (AMA)
Le May, Nicolas& Egly, Jean-Marc& Coin, Frédéric. True Lies : The Double Life of the Nucleotide Excision Repair Factors in Transcription and DNA Repair. Journal of Nucleic Acids. 2010. Vol. 2010, no. 2010, pp.1-10.
https://search.emarefa.net/detail/BIM-485402
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485402