![](/images/graphics-bg.png)
PPARs in Regulation of Paraoxonases : Control of Oxidative Stress and Inflammation Pathways
Joint Authors
Beltrán-Debón, Raúl
Joven, Jorge
Rull, Anna
Aragonès, Gerard
Camps, Jordi
Alonso-Villaverde, Carlos
García-Heredia, Anabel
Rodríguez-Gallego, Esther
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-24
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The paraoxonase (PON) group of enzymes, composed of PON1, PON2, and PON3, play an important role in decreasing oxidative stress by degrading lipid peroxides.
PON1 synthesis is upregulated by PPAR.
Several pharmacological compounds (acting as antioxidants and, hence, atheroprotective) stimulate both PPAR activity and PON1 expression.
Recent evidence suggests that PON1 and the monocyte chemoattractant protein-1 (MCP-1) are involved in coordinating the inflammatory response in damaged tissues; PPAR may be central in the regulation of these biochemical pathways.
This article reviews the state of knowledge on PON1 biochemistry and function, the influence of genetic variation, and the regulation of PON1 expression by pharmaceutical compounds that increase PPAR activity.
We also describe recent lines of evidence suggesting links between PON1 and MCP-1 and how their production may be regulated by PPAR.
American Psychological Association (APA)
Camps, Jordi& García-Heredia, Anabel& Rull, Anna& Alonso-Villaverde, Carlos& Aragonès, Gerard& Beltrán-Debón, Raúl…[et al.]. 2012. PPARs in Regulation of Paraoxonases : Control of Oxidative Stress and Inflammation Pathways. PPAR Research،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485404
Modern Language Association (MLA)
Camps, Jordi…[et al.]. PPARs in Regulation of Paraoxonases : Control of Oxidative Stress and Inflammation Pathways. PPAR Research No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-485404
American Medical Association (AMA)
Camps, Jordi& García-Heredia, Anabel& Rull, Anna& Alonso-Villaverde, Carlos& Aragonès, Gerard& Beltrán-Debón, Raúl…[et al.]. PPARs in Regulation of Paraoxonases : Control of Oxidative Stress and Inflammation Pathways. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-485404
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485404