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Preventive Strategies against Bleeding due to Nonvitamin K Antagonist Oral Anticoagulants
Joint Authors
Jean-Michel, Dogné
Maximilien, Gourdin
Bérangère, Devalet
Anne, Spinewine
Jean-Baptiste, Nicolas
François, Mullier
Jonathan, Douxfils
Sarah, Lessire
Anne-Sophie, Larock
Anne-Sophie, Dincq
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-16
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Dabigatran etexilate (DE), rivaroxaban, and apixaban are nonvitamin K antagonist oral anticoagulants (NOACs) that have been compared in clinical trials with existing anticoagulants (warfarin and enoxaparin) in several indications for the prevention and treatment of thrombotic events.
All NOACs presented bleeding events despite a careful selection and control of patients.
Compared with warfarin, NOACs had a decreased risk of intracranial hemorrhage, and apixaban and DE (110 mg BID) had a decreased risk of major bleeding from any site.
Rivaroxaban and DE showed an increased risk of major gastrointestinal bleeding compared with warfarin.
Developing strategies to minimize the risk of bleeding is essential, as major bleedings are reported in clinical practice and specific antidotes are currently not available.
In this paper, the following preventive approaches are reviewed: improvement of appropriate prescription, identification of modifiable bleeding risk factors, tailoring NOAC’s dose, dealing with a missed dose as well as adhesion to switching, bridging and anesthetic procedures.
American Psychological Association (APA)
Sarah, Lessire& Anne-Sophie, Dincq& Jonathan, Douxfils& Bérangère, Devalet& Jean-Baptiste, Nicolas& Anne, Spinewine…[et al.]. 2014. Preventive Strategies against Bleeding due to Nonvitamin K Antagonist Oral Anticoagulants. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-485407
Modern Language Association (MLA)
Sarah, Lessire…[et al.]. Preventive Strategies against Bleeding due to Nonvitamin K Antagonist Oral Anticoagulants. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-485407
American Medical Association (AMA)
Sarah, Lessire& Anne-Sophie, Dincq& Jonathan, Douxfils& Bérangère, Devalet& Jean-Baptiste, Nicolas& Anne, Spinewine…[et al.]. Preventive Strategies against Bleeding due to Nonvitamin K Antagonist Oral Anticoagulants. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-485407
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485407