Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever
Joint Authors
Choon, Tan Chwee
Muniandy, Prem Kumar
Thayan, Ravindran
Abdullah, Noor Rain
Subenthiran, Soobitha
Ismail, Zakiah
Teck, Mok Boon
Afzan, Adlin
Cheong, Kee Chee
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-11
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The study was conducted to investigate the platelet increasing property of Carica papaya leaves juice (CPLJ) in patients with dengue fever (DF).
An open labeled randomized controlled trial was carried out on 228 patients with DF and dengue haemorrhagic fever (DHF).
Approximately half the patients received the juice, for 3 consecutive days while the others remained as controls and received the standard management.
Their full blood count was monitored 8 hours for 48 hours.
Gene expression studies were conducted on the ALOX 12 and PTAFR genes.
The mean increase in platelet counts were compared in both groups using repeated measure ANCOVA.
There was a significant increase in mean platelet count observed in the intervention group (P<0.001) but not in the control group 40 hours since the first dose of CPLJ.
Comparison of mean platelet count between intervention and control group showed that mean platelet count in intervention group was significantly higher than control group after 40 and 48 hours of admission (P<0.01).
The ALOX 12 (FC = 15.00) and PTAFR (FC = 13.42) genes were highly expressed among those on the juice.
It was concluded that CPLJ does significantly increase the platelet count in patients with DF and DHF.
American Psychological Association (APA)
Subenthiran, Soobitha& Choon, Tan Chwee& Cheong, Kee Chee& Thayan, Ravindran& Teck, Mok Boon& Muniandy, Prem Kumar…[et al.]. 2013. Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485421
Modern Language Association (MLA)
Subenthiran, Soobitha…[et al.]. Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-485421
American Medical Association (AMA)
Subenthiran, Soobitha& Choon, Tan Chwee& Cheong, Kee Chee& Thayan, Ravindran& Teck, Mok Boon& Muniandy, Prem Kumar…[et al.]. Carica papaya Leaves Juice Significantly Accelerates the Rate of Increase in Platelet Count among Patients with Dengue Fever and Dengue Haemorrhagic Fever. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485421
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485421