Ghrelin : Central Nervous System Sites of Action in Regulation of Energy Balance
Joint Authors
Ferguson, Alastair V.
Fry, Mark
Source
International Journal of Peptides
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Ghrelin, a peptide hormone secreted by the stomach, has been shown to regulate energy homeostasis by modulating electrical activity of neurons in the central nervous system (CNS).
Like many circulating satiety signals, ghrelin is a peptide hormone and is unable to cross the blood-brain barrier without a transport mechanism.
In this review, we address the notion that the arcuate nucleus of the hypothalamus is the only site in the CNS that detects circulating ghrelin to trigger orexigenic responses.
We consider the roles of a specialized group of CNS structures called the sensory circumventricular organs (CVOs), which are not protected by the blood-brain barrier.
These areas include the subfornical organ and the area postrema and are already well known to be key areas for detection of other circulating hormones such as angiotensin II, cholecystokinin, and amylin.
A growing body of evidence indicates a key role for the sensory CVOs in the regulation of energy homeostasis.
American Psychological Association (APA)
Fry, Mark& Ferguson, Alastair V.. 2010. Ghrelin : Central Nervous System Sites of Action in Regulation of Energy Balance. International Journal of Peptides،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485422
Modern Language Association (MLA)
Fry, Mark& Ferguson, Alastair V.. Ghrelin : Central Nervous System Sites of Action in Regulation of Energy Balance. International Journal of Peptides No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-485422
American Medical Association (AMA)
Fry, Mark& Ferguson, Alastair V.. Ghrelin : Central Nervous System Sites of Action in Regulation of Energy Balance. International Journal of Peptides. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485422