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Mannan-Binding Lectin in Cardiovascular Disease
Joint Authors
Cedzynski, Maciej
Pągowska-Klimek, Izabela
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-30
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Cardiovascular disease remains the leading cause of mortality and morbidity worldwide so research continues into underlying mechanisms.
Since innate immunity and its potent component mannan-binding lectin have been proven to play an important role in the inflammatory response during infection and ischaemia-reperfusion injury, attention has been paid to its role in the development of cardiovascular complications as well.
This review provides a general outline of the structure and genetic polymorphism of MBL and its role in inflammation/tissue injury with emphasis on associations with cardiovascular disease.
MBL appears to be involved in the pathogenesis of atherosclerosis and, in consequence, coronary artery disease and also inflammation and tissue injury after myocardial infarction and heart transplantation.
The relationship between MBL and disease is rather complex and depends on different genetic and environmental factors.
That could be why the data obtained from animal and clinical studies are sometimes contradictory proving not for the first time that innate immunity is a “double-edge sword,” sometimes beneficial and, at other times disastrous for the host.
American Psychological Association (APA)
Pągowska-Klimek, Izabela& Cedzynski, Maciej. 2014. Mannan-Binding Lectin in Cardiovascular Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-485427
Modern Language Association (MLA)
Pągowska-Klimek, Izabela& Cedzynski, Maciej. Mannan-Binding Lectin in Cardiovascular Disease. BioMed Research International No. 2014 (2014), pp.1-13.
https://search.emarefa.net/detail/BIM-485427
American Medical Association (AMA)
Pągowska-Klimek, Izabela& Cedzynski, Maciej. Mannan-Binding Lectin in Cardiovascular Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-13.
https://search.emarefa.net/detail/BIM-485427
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485427