The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients
Joint Authors
Zegarska, Jolanta
Bodnar, Magdalena
Walentowicz, Pawel
Marszalek, Andrzej
Sokup, Alina
Walentowicz-Sadlecka, Małgorzata
Grabiec, Marek
Sadlecki, Pawel
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-03-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hypoxia-inducible factor-1α (HIF-1α), glucose transporter-1 (GLUT-1), and carbon anhydrase IX (CAIX) are important molecules that allow adaptation to hypoxic environments.
The aim of our study was to investigate the correlation between HIF-1α, GLUT-1, and CAIX protein level with the clinicopathological features of endometrial cancer patients.
Materials and Methods.
92 endometrial cancer patients, aged 37–84, were enrolled to our study.
In all patients clinical stage, histologic grade, myometrial invasion, lymph node, and distant metastases were determined.
Moreover, the survival time was assessed.
Immunohistochemical analyses were performed on archive formalin fixed paraffin embedded tissue sections.
Results.
High significant differences (P=0.0115) were reported between HIF-1α expression and the histologic subtype of cancer.
Higher HIF-1α expression was associated with the higher risk of recurrence (P=0.0434).
The results of GLUT-1 and CAIX expression did not reveal any significant differences between the proteins expression in the primary tumor and the clinicopathological features.
Conclusion.
The important role of HIF-1α in the group of patients with the high risk of recurrence and the negative histologic subtype of the tumor suggest that the expression of this factor might be useful in the panel of accessory pathomorphological tests and could be helpful in establishing more accurate prognosis in endometrial cancer patients.
American Psychological Association (APA)
Sadlecki, Pawel& Bodnar, Magdalena& Grabiec, Marek& Marszalek, Andrzej& Walentowicz, Pawel& Sokup, Alina…[et al.]. 2014. The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-485429
Modern Language Association (MLA)
Sadlecki, Pawel…[et al.]. The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-485429
American Medical Association (AMA)
Sadlecki, Pawel& Bodnar, Magdalena& Grabiec, Marek& Marszalek, Andrzej& Walentowicz, Pawel& Sokup, Alina…[et al.]. The Role of Hypoxia-Inducible Factor-1α, Glucose Transporter-1, (GLUT-1) and Carbon Anhydrase IX in Endometrial Cancer Patients. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-485429
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485429