The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice
Joint Authors
Reddy, Aravind T.
Lakshmi, Sowmya P.
Reddy, Raju C.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Acute lung injury (ALI) is an inflammatory condition culminating in respiratory failure.
There is currently no effective pharmacological treatment.
Nitrated fatty acids (NFAs) have been shown to exert anti-inflammatory effects.
We therefore hypothesized that delivery of NFAs directly to the site of inflammation would reduce the severity of ALI.
Pulmonary delivery of 10-nitro-oleate following endotoxin-induced ALI in mice reduced markers of lung inflammation and injury, including capillary leakage, lung edema, infiltration of neutrophils into the lung, and oxidant stress, as well as plasma levels of proinflammatory cytokines.
Nitro-oleate delivery likewise downregulated expression of proinflammatory genes by alveolar macrophages, key cells in regulation of lung inflammation.
These effects may be accounted for by the observed increases in the activity of PPAR-γ and the PPAR-γ-induced antioxidant transcription factor Nrf2, together with the decreased activity of NF-κB.
Our results demonstrate that pulmonary delivery of NFAs reduces severity of acute lung injury and suggest potential utility of these molecules in other inflammatory lung diseases.
American Psychological Association (APA)
Reddy, Aravind T.& Lakshmi, Sowmya P.& Reddy, Raju C.. 2012. The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice. PPAR Research،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-485446
Modern Language Association (MLA)
Reddy, Aravind T.…[et al.]. The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice. PPAR Research No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-485446
American Medical Association (AMA)
Reddy, Aravind T.& Lakshmi, Sowmya P.& Reddy, Raju C.. The Nitrated Fatty Acid 10-Nitro-oleate Diminishes Severity of LPS-Induced Acute Lung Injury in Mice. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-485446
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485446