Towards Personalized Medicine Based on Platelet Function Testing for Stent Thrombosis Patients
Joint Authors
Godschalk, Thea Cornelia
ten Berg, Jurriën Maria
Hackeng, Christian Marcus
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-25
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Stent thrombosis (ST) is a severe and feared complication of coronary stenting.
Patients who have suffered from ST are usually treated according to the “one-size-fits-all” dosing regimen of aspirin and clopidogrel.
Many ST patients show high on-treatment platelet reactivity (HPR) despite this antiplatelet therapy (APT).
It has been shown that HPR is a risk factor for major adverse cardiac events.
Therefore, ST patients with HPR are at a high risk for recurrent atherothrombotic events.
New insights into the variable response to clopidogrel and the advent of stronger P2Y12 inhibitors prasugrel and ticagrelor have changed the attention from a fixed APT treatment strategy towards “personalized APT strategies.” Strategies can be based on platelet function testing, which gives insight into the overall response of a patient to APT.
At our outpatient ST clinic, we practice personalized APT based on platelet function testing to guide the cardiologist to a presumed optimal antiplatelet treatment of ST patients.
Beside results of platelet function testing, comedication, clinical characteristics, and genetics have to be considered to decide on personalized APT.
Ongoing studies have yet to reveal the optimal personalized APT strategy for cardiologists to prevent their patients from atherothrombotic and bleeding events.
American Psychological Association (APA)
Godschalk, Thea Cornelia& Hackeng, Christian Marcus& ten Berg, Jurriën Maria. 2012. Towards Personalized Medicine Based on Platelet Function Testing for Stent Thrombosis Patients. Thrombosis،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-485451
Modern Language Association (MLA)
Godschalk, Thea Cornelia…[et al.]. Towards Personalized Medicine Based on Platelet Function Testing for Stent Thrombosis Patients. Thrombosis No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-485451
American Medical Association (AMA)
Godschalk, Thea Cornelia& Hackeng, Christian Marcus& ten Berg, Jurriën Maria. Towards Personalized Medicine Based on Platelet Function Testing for Stent Thrombosis Patients. Thrombosis. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-485451
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485451