Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate
Joint Authors
Prashanth, Kudige Nagaraj
Basavaiah, Kanakapura
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-27
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Rizatriptan is a new selective 5-HT1B/1D agonist which is used in the treatment of migraine headaches.
Two simple, rapid, accurate, and economical spectrophotometric methods are described for the determination of rizatriptan benzoate (RTB) in its pure form and pharmaceutical preparations.
These methods are based on the charge-transfer complexation reaction between rizatriptan benzoate as n-electron donor and p-chloranilic acid (p-CA) or 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as π-acceptor to form highly colored chromogens.
The chromogens formed by the reaction between RTB and p-CA peaked at 530 nm (method A) and that formed by the reaction between RTB and DDQ peaked at 590 nm (method B).
Under the optimum conditions Beer’s law is obeyed in the concentration range of 14–245 μg mL−1 for method A and 4–70 μg mL−1 for method B.
The coefficient of correlation was found to be 0.9999 for both methods.
The molar absorptivity, Sandell sensitivity, limits of detection, and quantification are also reported.
The stoichiometric relationship determined by Job’s continuous method was found to be 1 : 1 (drug : reagent) for both methods.
Both methods were applied to determination of RTB in the pharmaceutical formulations.
Results of the analysis were validated statistically.
American Psychological Association (APA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura. 2012. Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate. ISRN Analytical Chemistry،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-485458
Modern Language Association (MLA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura. Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate. ISRN Analytical Chemistry No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-485458
American Medical Association (AMA)
Prashanth, Kudige Nagaraj& Basavaiah, Kanakapura. Utility of p-Chloranilic Acid and 2,3-Dichloro-5,6-dicyano-p-benzoquinone for the Spectrophotometric Determination of Rizatriptan Benzoate. ISRN Analytical Chemistry. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-485458
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485458