![](/images/graphics-bg.png)
Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery : In-Vitro Analysis
Joint Authors
Ouyang, Wei
Prakash, Satya
Chen, Hongmei
Martoni, Christopher
Source
International Journal of Polymer Science
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-18
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
We have previously reported the preparation of the genipin cross-linked alginate-chitosan (GCAC) microcapsules composed of an alginate core with a genipin cross-linked chitosan membrane.
This paper is the further investigation on their structural and physical characteristics.
Results showed that the GCAC microcapsules had a smooth and dense surface and a networked interior.
Cross-linking by genipin substantially reduced swelling and physical disintegration of microcapsules induced by nongelling ions and calcium sequestrants.
Strong resistance to mechanical shear forces and enzymatic degradation was observed.
Furthermore, the GCAC membranes were permeable to bovine serum albumin and maintained a molecular weight cutoff at 70 KD, analogous to the widely studied alginate-chitosan, and alginate-poly-L-lysine-alginate microcapsules.
The release features and the tolerance of the GCAC microcapsules in the stimulated gastrointestinal environment were also investigated.
This GCAC microcapsule formulation offers significant potential as a delivery vehicle for many biomedical applications.
American Psychological Association (APA)
Chen, Hongmei& Ouyang, Wei& Martoni, Christopher& Prakash, Satya. 2009. Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery : In-Vitro Analysis. International Journal of Polymer Science،Vol. 2009, no. 2009, pp.1-16.
https://search.emarefa.net/detail/BIM-485459
Modern Language Association (MLA)
Chen, Hongmei…[et al.]. Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery : In-Vitro Analysis. International Journal of Polymer Science No. 2009 (2009), pp.1-16.
https://search.emarefa.net/detail/BIM-485459
American Medical Association (AMA)
Chen, Hongmei& Ouyang, Wei& Martoni, Christopher& Prakash, Satya. Genipin Cross-Linked Polymeric Alginate-Chitosan Microcapsules for Oral Delivery : In-Vitro Analysis. International Journal of Polymer Science. 2009. Vol. 2009, no. 2009, pp.1-16.
https://search.emarefa.net/detail/BIM-485459
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485459