Resveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury Induced by Inorganic Arsenic Exposure
Joint Authors
Jiang, Jing
Cheng, Yanyan
Gao, Li
Chen, Yan
Jiang, Huijie
Yu, Hongxiang
Cheng, Baojing
Shan, Anshan
Zhang, Zhigang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-07-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Resveratrol (Rev) can ameliorate cytotoxic chemotherapy-induced toxicity and oxidative stress.
Arsenic trioxide (As2O3) is a known cytotoxic environmental toxicant and a potent chemotherapeutic agent.
However, the mechanisms by which resveratrol protects the liver against the cytotoxic effects of As2O3 are not known.
Therefore, in the present study we investigated the mechanisms involved in the action of resveratrol using a cat model in which hepatotoxicity was induced by means of As2O3 treatment.
We found that pretreatment with resveratrol, administered using a clinically comparable dose regimen, reversed changes in As2O3-induced morphological and liver parameters and resulted in a significant improvement in hepatic function.
Resveratrol treatment also improved the activities of antioxidant enzymes and attenuated As2O3-induced increases in reactive oxygen species and malondialdehyde production.
In addition, resveratrol attenuated the As2O3-induced reduction in the ratio of reduced glutathione to oxidized glutathione and the retention of arsenic in liver tissue.
These findings provide a better understanding of the mechanisms whereby resveratrol modulates As2O3-induced changes in liver function and tissue morphology.
They also provide a stronger rationale for the clinical utilization of resveratrol for the reduction of As2O3-induced hepatotoxicity.
American Psychological Association (APA)
Zhang, Zhigang& Gao, Li& Cheng, Yanyan& Jiang, Jing& Chen, Yan& Jiang, Huijie…[et al.]. 2014. Resveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury Induced by Inorganic Arsenic Exposure. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-485461
Modern Language Association (MLA)
Zhang, Zhigang…[et al.]. Resveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury Induced by Inorganic Arsenic Exposure. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-485461
American Medical Association (AMA)
Zhang, Zhigang& Gao, Li& Cheng, Yanyan& Jiang, Jing& Chen, Yan& Jiang, Huijie…[et al.]. Resveratrol, a Natural Antioxidant, Has a Protective Effect on Liver Injury Induced by Inorganic Arsenic Exposure. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-485461
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485461