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Lymphotoxin-Alpha Gene Polymorphism +252AG (rs909253, AG) Is Associated with Susceptibility to Chronic Periodontitis : A Pilot Study
Joint Authors
de Brito Júnior, Rui Barbosa
Vasconcelos, Daniel Fernando Pereira
Barros, Silvana Pereira
Marques, Marcelo Rocha
Vasconcelos, Any Carolina Cardoso Guimarães
da Silva, Marco Antônio Dias
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Periodontal disease leading to clinical findings such as increased periodontal probing depth involves a complex interaction between invading pathogenic microorganisms and the patient's immune system.
Lymphotoxin alpha (LT-α) is a potent multifunctional immune modulator that contributes toward susceptibility to immune regulation disorders, including periodontal disease.
Objective.
In this study, we tested the hypothesis that chronic periodontitis (CP) is associated with polymorphisms of the LT-α gene.
Materials and Methods.
A total of 126 subjects, 44 healthy subjects, and 82 subjects with CP, were evaluated for periodontal disease by measuring clinical attachment loss and separation.
Samples of epithelial cells were obtained for DNA analysis by scraping of the buccal mucosa.
The LT-α gene was analyzed by polymerase chain reaction followed by endonuclease digestion with NcoI to analyze restriction fragment length polymorphisms.
Results.
The LT-α gene (+252A/G) polymorphism was associated with CP.
LT-α allele frequencies were significantly different (P=0.0019) between patients with CP and healthy individuals, with an odds ratio of 2.67 for patients with CP with the G allele.
Conclusions.
These findings suggest the LT-α gene genotype is a risk indicator for susceptibility to chronic periodontal disease in the Brazilian population studied.
American Psychological Association (APA)
Vasconcelos, Daniel Fernando Pereira& da Silva, Marco Antônio Dias& Marques, Marcelo Rocha& de Brito Júnior, Rui Barbosa& Vasconcelos, Any Carolina Cardoso Guimarães& Barros, Silvana Pereira. 2012. Lymphotoxin-Alpha Gene Polymorphism +252AG (rs909253, AG) Is Associated with Susceptibility to Chronic Periodontitis : A Pilot Study. ISRN Dentistry،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-485470
Modern Language Association (MLA)
Vasconcelos, Daniel Fernando Pereira…[et al.]. Lymphotoxin-Alpha Gene Polymorphism +252AG (rs909253, AG) Is Associated with Susceptibility to Chronic Periodontitis : A Pilot Study. ISRN Dentistry No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-485470
American Medical Association (AMA)
Vasconcelos, Daniel Fernando Pereira& da Silva, Marco Antônio Dias& Marques, Marcelo Rocha& de Brito Júnior, Rui Barbosa& Vasconcelos, Any Carolina Cardoso Guimarães& Barros, Silvana Pereira. Lymphotoxin-Alpha Gene Polymorphism +252AG (rs909253, AG) Is Associated with Susceptibility to Chronic Periodontitis : A Pilot Study. ISRN Dentistry. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-485470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485470