Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats
Joint Authors
Bao, Feng-Wei
Cai, Qian
Zhang, Zhen-Qiu
Liu, Yu-Qiang
Liu, Chang
Source
Journal of Analytical Methods in Chemistry
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-02-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A simple and sensitive HPLC method was developed for simultaneous determination of danshensu (DSS), rosmarinic acid (RA), lithospermic acid (LA), salvianolic acid B (SAB), and hyperoside (HP) in rat plasma.
This method validated was successfully applied to the pharmacokinetic study of the main active ingredients after oral administration of Radix Salviae Miltiorrhizae extract (SME), hawthorn extract (HTE), and a combination of both extracts (2.5 : 1) to rats.
The results indicated that there have been great differences in pharmacokinetics between a single extract and a combination of both extracts.
A combination of both extracts can enhance their bioavailabilities and delay the elimination of SAB and DSS in rats.
American Psychological Association (APA)
Liu, Yu-Qiang& Cai, Qian& Liu, Chang& Bao, Feng-Wei& Zhang, Zhen-Qiu. 2014. Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats. Journal of Analytical Methods in Chemistry،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-485485
Modern Language Association (MLA)
Liu, Yu-Qiang…[et al.]. Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats. Journal of Analytical Methods in Chemistry No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-485485
American Medical Association (AMA)
Liu, Yu-Qiang& Cai, Qian& Liu, Chang& Bao, Feng-Wei& Zhang, Zhen-Qiu. Simultaneous Determination and Pharmacokinetic Comparisons of Multi-Ingredients after Oral Administration of Radix Salviae Miltiorrhizae Extract, Hawthorn Extract, and a Combination of Both Extracts to Rats. Journal of Analytical Methods in Chemistry. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-485485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485485
