Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease
Joint Authors
Van Dam, Debby
Audenaert, Kurt
Wostyn, Peter
De Deyn, Peter Paul
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Alzheimer's disease (AD), the most common type of dementia among older people, is characterized by the accumulation of β-amyloid (Aβ) senile plaques and neurofibrillary tangles composed of hyperphosphorylated tau in the brain.
Despite major advances in understanding the molecular etiology of the disease, progress in the clinical treatment of AD patients has been extremely limited.
Therefore, new and more effective therapeutic approaches are needed.
Accumulating evidence from human and animal studies suggests that the long-term consumption of caffeine, the most commonly used psychoactive drug in the world, may be protective against AD.
The mechanisms underlying the suggested beneficial effect of caffeine against AD remain to be elucidated.
In recent studies, several potential neuroprotective effects of caffeine have been proposed.
Interestingly, a recent study in rats showed that the long-term consumption of caffeine increased cerebrospinal fluid (CSF) production, associated with the increased expression of Na+-K+ ATPase and increased cerebral blood flow.
Compromised function of the choroid plexus and defective CSF production and turnover, with diminished clearance of Aβ, may be one mechanism implicated in the pathogenesis of late-onset AD.
If reduced CSF turnover is a risk factor for AD, then therapeutic strategies to improve CSF flow are reasonable.
In this paper, we hypothesize that long-term caffeine consumption could exert protective effects against AD at least in part by facilitating CSF production, turnover, and clearance.
Further, we propose a preclinical experimental design allowing evaluation of this hypothesis.
American Psychological Association (APA)
Wostyn, Peter& Van Dam, Debby& Audenaert, Kurt& De Deyn, Peter Paul. 2011. Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485490
Modern Language Association (MLA)
Wostyn, Peter…[et al.]. Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-485490
American Medical Association (AMA)
Wostyn, Peter& Van Dam, Debby& Audenaert, Kurt& De Deyn, Peter Paul. Increased Cerebrospinal Fluid Production as a Possible Mechanism Underlying Caffeine's Protective Effect against Alzheimer's Disease. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485490
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485490