Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination
Joint Authors
Takao, Masakatsu
Kawakita, Takuya
Kudo, Chiaki
Uruse, Michihiro
Yasukawa, Akio
Asou, Hiroaki
Yamamoto, Masahiro
Hasegawa, Atsuhiko
Ishige, Atushi
Komatsu, Yasuhiro
Seiwa, Chika
Tanaka, Kayoko
Watanabe, Kenji
Sato, Nanako
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The disruption of myelin causes severe neurological diseases.
An understanding of the mechanism of myelination and remyelination is essential for the development of therapeutic strategies for demyelination diseases.
Our previous findings indicated that the FcRγ/Fyn cascade is a potential therapeutic target for remyelination caused by the Chinese/Japanese traditional herbal (Kampo) medicine ninjin’youeito (Ninjin-youei-to, NYT), which is a hot-water extract made from 12 medicinal herbs.
To identify which constituents of NYT are involved in the reversal of demyelination and to examine the potential therapeutic effect, we tested several of the chemical constituents of NYT.
Here, we report that Chinpi, a constituent of NYT, upregulates the FcRγ/Fyn signaling cascade resulting in a potentially therapeutic effect against age-induced demyelination.
In addition, we observed that phosphorylated (activated) FcRγ/Fyn upregulated the expression of the 21.5 kDa isoform of myelin basic protein, inducing rapid morphological differentiation, when oligodendrocyte precursor cells (OPCs) were cultured in the presence of hesperidin and/or narirutin (the major active constituents of Chinpi).
These results suggest that hesperidin and narirutin participate in the FcRγ/Fyn signaling pathway in OPCs causing these cells to differentiate into myelinating oligodendrocytes.
American Psychological Association (APA)
Sato, Nanako& Seiwa, Chika& Uruse, Michihiro& Yamamoto, Masahiro& Tanaka, Kayoko& Kawakita, Takuya…[et al.]. 2011. Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485493
Modern Language Association (MLA)
Sato, Nanako…[et al.]. Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485493
American Medical Association (AMA)
Sato, Nanako& Seiwa, Chika& Uruse, Michihiro& Yamamoto, Masahiro& Tanaka, Kayoko& Kawakita, Takuya…[et al.]. Administration of Chinpi, a Component of the Herbal Medicine Ninjin-Youei-To, Reverses Age-Induced Demyelination. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485493
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485493