Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone
Joint Authors
Yu, Lu
Guo, Na
Liu, Guowen
Xiang, Hua
Zhang, Jiyu
Wang, Xuelin
Wu, Xiuping
Deng, Xuming
Feng, Haihua
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-08-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Staphylococcus aureus (S.
aureus) strains with multiple antibiotic resistances are increasingly widespread, and new agents are required for the treatment of S.
aureus.
Cryptotanshinone (CT), a major tanshinone of medicinal plant Salvia miltiorrhiza Bunge, demonstrated effective in vitro antibacterial activity against all 21 S.
aureus strains tested in this experiment.
Affymetrix GeneChips were utilized to determine the global transcriptional response of S.
aureus ATCC 25923 to treatment with subinhibitory concentrations of CT.
Transcriptome profiling indicated that the antibacterial action of CT may be associated with its action as active oxygen radical generator; S.
aureus undergoes an oxygen-limiting state upon exposure to CT.
American Psychological Association (APA)
Feng, Haihua& Xiang, Hua& Zhang, Jiyu& Liu, Guowen& Guo, Na& Wang, Xuelin…[et al.]. 2009. Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone. Journal of Biomedicine and Biotechnology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-485504
Modern Language Association (MLA)
Feng, Haihua…[et al.]. Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone. Journal of Biomedicine and Biotechnology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-485504
American Medical Association (AMA)
Feng, Haihua& Xiang, Hua& Zhang, Jiyu& Liu, Guowen& Guo, Na& Wang, Xuelin…[et al.]. Genome-Wide Transcriptional Profiling of the Response of Staphylococcus aureus to Cryptotanshinone. Journal of Biomedicine and Biotechnology. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-485504
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485504