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Drug Resistance in Visceral Leishmaniasis
Author
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-11-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Visceral leishmaniasis remains a public health problem worldwide.
This illness was included by the World Health Organization in the list of neglected tropical diseases targeted for elimination by 2015.
The widespread emergence of resistance to pentavalent antimonials in India where half cases occur globally and the unavailability of a vaccine in clinical use constitute major obstacles in achieving this goal.
The last decade new antileishmanials became available, including the oral agent miltefosine.
However, in poor endemic countries their wide use was curtailed because of the high costs, and also due to concerns of toxicity and emergence of resistance.
Various mechanisms of antileishmanial resistance were identified recently in field isolates.
Their elucidation will boost the design of new drugs and the molecular surveillance of resistance.
Combination regimens should be evaluated in large trials.
Overall, the development of antileishmanials has been generally slow; new drugs are needed.
In order to control visceral leishmaniasis worldwide, treatment advances should become affordable in the poorest countries, where they are needed most.
American Psychological Association (APA)
Maltezou, Helena C.. 2009. Drug Resistance in Visceral Leishmaniasis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485505
Modern Language Association (MLA)
Maltezou, Helena C.. Drug Resistance in Visceral Leishmaniasis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-485505
American Medical Association (AMA)
Maltezou, Helena C.. Drug Resistance in Visceral Leishmaniasis. Journal of Biomedicine and Biotechnology. 2009. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-485505
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485505