Acute Kidney Injury in ADPKD Patients with Pneumonia
Joint Authors
Keddis, Mira T.
Zand, Ladan
Qin, Dingxin
Wang, Xiangling
Hartman, Robert P.
Cartin-Ceba, Rodrigo
Li, Guangxi
Franco Palacios, Carlos
Qian, Qi
Source
International Journal of Nephrology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
In animal models, polycystic kidneys are susceptible to acute kidney injury (AKI).
We examined the occurrence of AKI in a cohort of autosomal dominant polycystic kidney disease (ADPKD) and non-ADPKD patients with acute pneumonia.
Design.
All ADPKD patients admitted to Mayo Clinic Rochester for pneumonia from January 1990 to April 2010 were examined.
Sixty-three patients had lobar infiltration and consolidation on chest X-ray.
After excluding patients on dialysis, with organ transplantation, and on chronic immunosuppression, 24 remaining ADPKD patients were enrolled.
Twenty-three of the 24 were matched with 92 (1 : 4 ratio) non-ADPKD pneumonia patients based on their baseline eGFR.
AKI was defined as serum creatinine elevation ≥0.3 mg/dL.
Results.
Sixteen of the 23 ADPKD patients (69.6%) and 36 of the 92 (39.1%) non-ADPKD patients developed AKI, P=0.008.
In both groups, those who developed AKI had a lower baseline eGFR (41.1±5.00 versus 58.7±11.8 in ADPKD and 40.2±3.65 versus 51.8±2.24 mL/min/1.73 m2 in the non-ADPKD group), more intensive care unit admissions, and longer hospital stays.
AKI was associated with a reduced survival in both groups.
Conclusions.
Patients with ADPKD admitted for acute pneumonia had more frequent episodes of AKI than non-ADPKD patients with comparable kidney function.
American Psychological Association (APA)
Franco Palacios, Carlos& Keddis, Mira T.& Qin, Dingxin& Zand, Ladan& Li, Guangxi& Wang, Xiangling…[et al.]. 2011. Acute Kidney Injury in ADPKD Patients with Pneumonia. International Journal of Nephrology،Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485535
Modern Language Association (MLA)
Franco Palacios, Carlos…[et al.]. Acute Kidney Injury in ADPKD Patients with Pneumonia. International Journal of Nephrology No. 2011 (2011), pp.1-6.
https://search.emarefa.net/detail/BIM-485535
American Medical Association (AMA)
Franco Palacios, Carlos& Keddis, Mira T.& Qin, Dingxin& Zand, Ladan& Li, Guangxi& Wang, Xiangling…[et al.]. Acute Kidney Injury in ADPKD Patients with Pneumonia. International Journal of Nephrology. 2011. Vol. 2011, no. 2011, pp.1-6.
https://search.emarefa.net/detail/BIM-485535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485535