Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes
Joint Authors
Gavrilova, Elena V.
Kochneva, Galina V.
Maksyutov, Rinat A.
Shchelkunov, Sergei N.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-21
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
DNA vaccines combining plasmids carrying the variola virus genes M1R, A30L, and F8L of intracellular virion surface membrane proteins as well as A36R and B7R of the extracellular virus envelope proteins under control of Rous sarcoma virus or cytomegalovirus promoters have been constructed.
These DNA vaccines induced production of a high titers of vaccinia virus-neutralizing antibodies in mice similar to those elicited by the live vaccinia virus immunization.
Mice vaccinated by created DNA vaccine were completely protected against a lethal (10 LD50) challenge with highly pathogenic ectromelia virus.
These results suggest that such vaccine should be efficient in immunization of humans against smallpox.
American Psychological Association (APA)
Maksyutov, Rinat A.& Gavrilova, Elena V.& Kochneva, Galina V.& Shchelkunov, Sergei N.. 2012. Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes. Journal of Vaccines،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-485574
Modern Language Association (MLA)
Maksyutov, Rinat A.…[et al.]. Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes. Journal of Vaccines No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-485574
American Medical Association (AMA)
Maksyutov, Rinat A.& Gavrilova, Elena V.& Kochneva, Galina V.& Shchelkunov, Sergei N.. Immunogenicity and Protective Efficacy of a Polyvalent DNA Vaccine against Human Orthopoxvirus Infections Based on Smallpox Virus Genes. Journal of Vaccines. 2012. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-485574
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485574
