17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats
Joint Authors
Lakshmanaswamy, Rajkumar
White, Steven K.
Trauger, Richard J.
Ahlem, Clarence N.
Frincke, James M.
Reading, Christopher L.
Source
International Journal of Breast Cancer
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-14
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
N-methyl-N-nitrosourea (MNU) induces estrogen-dependent mammary tumors in female Lewis rats.
We explored the antineoplastic activity of a synthetic androstane derivative, 17α-ethynyl-5α-androstane-3α, 17β-diol (HE3235), as a single agent or in combination with docetaxel compared to tamoxifen, anastrazole, and docetaxel monotherapies against MNU-induced mammary tumors in female Lewis rats.
Treatment with HE3235 alone rapidly reduced tumor burden, similar in effect to tamoxifen and anastrozole.
The combination of HE3235 with docetaxel was more effective than any single agent, although without apparent toxicity.
Only HE3235 or HE3235 plus docetaxel continued to suppress tumor growth after cessation of treatment.
HE3235 treatment increased immunohistochemical markers of apoptosis and expression of proapoptotic genes and estrogen receptor beta and decreased expression of antiapoptotic genes, androgen receptor, and estrogen receptor alpha.
These data warrant clinical investigation of HE3235 for breast cancer treatment.
American Psychological Association (APA)
Ahlem, Clarence N.& Frincke, James M.& White, Steven K.& Reading, Christopher L.& Trauger, Richard J.& Lakshmanaswamy, Rajkumar. 2011. 17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats. International Journal of Breast Cancer،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485618
Modern Language Association (MLA)
Ahlem, Clarence N.…[et al.]. 17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats. International Journal of Breast Cancer No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485618
American Medical Association (AMA)
Ahlem, Clarence N.& Frincke, James M.& White, Steven K.& Reading, Christopher L.& Trauger, Richard J.& Lakshmanaswamy, Rajkumar. 17α-Ethynyl-5α-androstane-3α, 17β-diol Treatment of MNU-Induced Mammary Cancer in Rats. International Journal of Breast Cancer. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485618
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485618