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Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs
Joint Authors
Walters, John M.
Ogilvie, Gregory K.
Hackett, Timothy B.
Fettman, Martin J.
Source
Veterinary Medicine International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-27
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Polyunsaturated fatty acids (PUFAs) have anti-inflammatory effects at low concentrations; however increased dietary consumption may conversely increase susceptibility to oxidation by free radicals.
The objective of this study was to determine the effects of PUFAs on selective oxidative injury and inflammatory biomarkers in canine urine and serum.
Dogs (n=54) consumed a diet supplemented with 0.5% conjugated linoleic acid/dry matter, 1.0% conjugated linoleic acid/dry matter, or 200 mg/kg docosahexaenoic acid/eicosapentaenoic acid for 21 days.
All dogs exhibited significantly increased plasma PUFA concentrations.
All dogs had significant elevations in urinary F2a isoprostane concentration, though dogs consuming a diet containing 1.0% conjugated linoleic acid/dry matter had the highest increase (P=.0052).
Reduced glutathione concentrations within erythrocytes decreased significantly in all three dietary treatment groups (P=.0108).
Treatment with diets containing 1.0% conjugated linoleic acid/dry matter resulted in the greatest increase in oxidant injury.
Caution should be exercised when supplementing PUFAs as some types may increase oxidation.
American Psychological Association (APA)
Walters, John M.& Hackett, Timothy B.& Ogilvie, Gregory K.& Fettman, Martin J.. 2010. Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs. Veterinary Medicine International،Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-485644
Modern Language Association (MLA)
Walters, John M.…[et al.]. Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs. Veterinary Medicine International No. 2010 (2010), pp.1-4.
https://search.emarefa.net/detail/BIM-485644
American Medical Association (AMA)
Walters, John M.& Hackett, Timothy B.& Ogilvie, Gregory K.& Fettman, Martin J.. Polyunsaturated Fatty Acid Dietary Supplementation Induces Lipid Peroxidation in Normal Dogs. Veterinary Medicine International. 2010. Vol. 2010, no. 2010, pp.1-4.
https://search.emarefa.net/detail/BIM-485644
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485644