![](/images/graphics-bg.png)
A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia
Joint Authors
Source
Case Reports in Transplantation
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-10
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a most powerful immunotherapy for hematological malignancies.
However, the impact of immunological disturbances as a result of allo-HSCT is not understood well.
We experienced an 11-year-old boy who presented with systemic lupus erythemathosus (SLE) 10 years after unrelated cord blood transplantation of male origin for juvenile myelomonocytic leukemia (JMML) with monosomy 7.
Bone marrow examination showed complete remission without monosomy 7.
Genetic analysis of peripheral blood revealed mixed chimera with recipient cells consisting of <5% of T cells, 50–60% of B cells, 60–75% of NK cells, 70–80% of macrophages, and 50–60% of granulocytes.
Significance of persistent mixed chimera as a cause of SLE is discussed.
American Psychological Association (APA)
Nagasawa, Masayuki& Aoki, Yuki. 2012. A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia. Case Reports in Transplantation،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-485649
Modern Language Association (MLA)
Nagasawa, Masayuki& Aoki, Yuki. A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia. Case Reports in Transplantation No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-485649
American Medical Association (AMA)
Nagasawa, Masayuki& Aoki, Yuki. A Pediatric Case of Systemic Lupus Erythematosus Developed 10 Years after Cord Blood Transplantation for Juvenile Myelomonocytic Leukemia. Case Reports in Transplantation. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-485649
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485649