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Neopterin as a Marker of Response to Antiviral Therapy in Hepatitis C Virus Patients
Joint Authors
Viveiros, Kathleen
Lee, Hannah
Summergrad, Paul
Requintina, Pura J.
Ruthazer, Robin
Mikolich, Dennis L.
Oxenkrug, Gregory F.
Source
Hepatitis Research and Treatment
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Predicting the efficacy of antiviral treatment of hepatitis C virus (HCV) is of importance for both patient well-being and health care expense.
The expression of interferon-stimulated genes (IFN-SGs) in the liver was suggested as a marker of response to anti-viral therapy.
IFN-SGs encode the guanosine triphosphate cyclohydrolase 1 (GTPCH), a rate-limiting enzyme of pteridines biosynthesis.
Neopterin, a stable byproduct of GTPCH-catalyzed reaction, is used as a marker of interferon-induced GTPCH activation.
We hypothesized that assessment of neopterin concentrations might predict the response to antiviral therapy.
Neopterin concentrations were evaluated in 260 HCV patients treated by pegylated interferon combined with ribavirin.
Mean and median pretreatment neopterin concentrations were lower in patients with sustained virological response than in nonresponders.
The rate of response was twofold higher among patients with pretreatment neopterin levels <16 nmol/L than in patients with neopterin levels ≥16 nmol/L, even after controlling for HCV genotype status.
Our study suggests that the pretreatment level of neopterin might be used in routine clinical practice as rapid and cost-effective marker to predict the response to antiviral therapy in HCV patients.
American Psychological Association (APA)
Oxenkrug, Gregory F.& Requintina, Pura J.& Mikolich, Dennis L.& Ruthazer, Robin& Viveiros, Kathleen& Lee, Hannah…[et al.]. 2012. Neopterin as a Marker of Response to Antiviral Therapy in Hepatitis C Virus Patients. Hepatitis Research and Treatment،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-485697
Modern Language Association (MLA)
Oxenkrug, Gregory F.…[et al.]. Neopterin as a Marker of Response to Antiviral Therapy in Hepatitis C Virus Patients. Hepatitis Research and Treatment No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-485697
American Medical Association (AMA)
Oxenkrug, Gregory F.& Requintina, Pura J.& Mikolich, Dennis L.& Ruthazer, Robin& Viveiros, Kathleen& Lee, Hannah…[et al.]. Neopterin as a Marker of Response to Antiviral Therapy in Hepatitis C Virus Patients. Hepatitis Research and Treatment. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-485697
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485697