The Role of HCN Channels on Membrane Excitability in the Nervous System
Joint Authors
Source
Journal of Signal Transduction
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels were first reported in heart cells and are recently known to be involved in a variety of neural functions in healthy and diseased brains.
HCN channels generate inward currents when the membrane potential is hyperpolarized.
Voltage dependence of HCN channels is regulated by intracellular signaling cascades, which contain cyclic AMP, PIP2, and TRIP8b.
In addition, voltage-gated potassium channels have a strong influence on HCN channel activity.
Because of these funny features, HCN channel currents, previously called funny currents, can have a wide range of functions that are determined by a delicate balance of modulatory factors.
These multifaceted features also make it difficult to predict and elucidate the functional role of HCN channels in actual neurons.
In this paper, we focus on the impacts of HCN channels on neural activity.
The functions of HCN channels reported previously will be summarized, and their mechanisms will be explained by using numerical simulation of simplified model neurons.
American Psychological Association (APA)
Kase, Daisuke& Imoto, Keiji. 2012. The Role of HCN Channels on Membrane Excitability in the Nervous System. Journal of Signal Transduction،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-485712
Modern Language Association (MLA)
Kase, Daisuke& Imoto, Keiji. The Role of HCN Channels on Membrane Excitability in the Nervous System. Journal of Signal Transduction No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-485712
American Medical Association (AMA)
Kase, Daisuke& Imoto, Keiji. The Role of HCN Channels on Membrane Excitability in the Nervous System. Journal of Signal Transduction. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-485712
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485712