Lingmao Formula Combined with Entecavir for HBeAg-Positive Chronic Hepatitis B Patients with Mildly Elevated Alanine Aminotransferase : A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
Joint Authors
Liu, Shun-Qing
Gao, Yue-Qiu
Li, Lu
Li, Man
Zhou, Zheng-Hua
Sun, Xue-Hua
Lv, Hua
Zhu, Xiao-Jun
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-24
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Objective.
To determine the efficacy and safety of Lingmao Formula combined with entecavir for HBeAg-positive chronic hepatitis B patients with mildly elevated alanine aminotransferase (ALT).
Methods.
301 patients were randomly assigned to receive Lingmao Formula combined with entecavir (treatment group) or placebo combined with entecavir (control group) for 52 weeks.
The outcomes of interest included the reduction of serum HBV DNA level, HBeAg loss, HBeAg seroconversion, ALT normalization, and histological improvement.
Results.
The mean decrease of serum HBV DNA level from baseline and the percentage of patients who had reduction in serum HBV DNA level ≥2 lg copies/mL in treatment group were significantly greater than that in control group (5.5 versus 5.4 lg copies/mL, P=0.010; 98.5% versus 92.6%, P=0.019).
The percentage of HBeAg loss in treatment group was 22.8%, which was much higher than a percentage of 12.6% in control group (P=0.038).
There was no significant difference between the two groups in histological improvement.
Safety was similar in the two groups.
Conclusions.
The combination of Lingmao Formula with entecavir could result in significant decrease of serum HBV DNA and increase of HBeAg loss for HBeAg-positive chronic hepatitis B patients with mildly elevated ALT without any serious adverse events.
Clinical trial registration number is ChiCTR-TRC-09000594.
American Psychological Association (APA)
Zhu, Xiao-Jun& Sun, Xue-Hua& Zhou, Zheng-Hua& Liu, Shun-Qing& Lv, Hua& Li, Man…[et al.]. 2013. Lingmao Formula Combined with Entecavir for HBeAg-Positive Chronic Hepatitis B Patients with Mildly Elevated Alanine Aminotransferase : A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485732
Modern Language Association (MLA)
Zhu, Xiao-Jun…[et al.]. Lingmao Formula Combined with Entecavir for HBeAg-Positive Chronic Hepatitis B Patients with Mildly Elevated Alanine Aminotransferase : A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-485732
American Medical Association (AMA)
Zhu, Xiao-Jun& Sun, Xue-Hua& Zhou, Zheng-Hua& Liu, Shun-Qing& Lv, Hua& Li, Man…[et al.]. Lingmao Formula Combined with Entecavir for HBeAg-Positive Chronic Hepatitis B Patients with Mildly Elevated Alanine Aminotransferase : A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-485732
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485732