Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder
Joint Authors
Rao Chamallamudi, Mallikarjuna
Shenoy, Gautham G.
Mudgal, Jayesh
Manohara Reddy, Seethappa A.
Nampurath, Gopalan K.
Valiathan, Manna
Gowdra, Vasantharaju S.
Nayak, Pawan G.
Bansal, Punit
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-22
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We synthesized twenty thiazolidin-4-one derivatives, which were then characterized by standard chromatographic and spectroscopic methods.
From the in vitro glucose uptake assay, two compounds behaved as insulin sensitizers, where they enhanced glucose uptake in isolated rat diaphragm.
In high-carbohydrate diet-induced insulin resistant mice, these two thiazolidin-4-ones attenuated hyperglycemia, hyperinsulinemia, hypertriglyceridemia, hypercholesterolemia, and glucose intolerance.
They raised the plasma leptin but did not reverse the diabetes-induced hypoadiponectinemia.
Additionally, compound 3a reduced adiposity.
The test compounds were also able to reverse the disturbed liver antioxidant milieu.
To conclude, these two novel thiazolidin-4-ones modulated multiple mechanisms involved in metabolic disorders, reversing insulin resistance and thus preventing the development of type-2 diabetes.
American Psychological Association (APA)
Gowdra, Vasantharaju S.& Mudgal, Jayesh& Bansal, Punit& Nayak, Pawan G.& Manohara Reddy, Seethappa A.& Shenoy, Gautham G.…[et al.]. 2014. Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder. BioMed Research International،Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-485759
Modern Language Association (MLA)
Gowdra, Vasantharaju S.…[et al.]. Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder. BioMed Research International No. 2014 (2014), pp.1-14.
https://search.emarefa.net/detail/BIM-485759
American Medical Association (AMA)
Gowdra, Vasantharaju S.& Mudgal, Jayesh& Bansal, Punit& Nayak, Pawan G.& Manohara Reddy, Seethappa A.& Shenoy, Gautham G.…[et al.]. Synthesis, Characterization, and Preclinical Evaluation of New Thiazolidin-4-ones Substituted with p-Chlorophenoxy Acetic Acid and Clofibric Acid against Insulin Resistance and Metabolic Disorder. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-14.
https://search.emarefa.net/detail/BIM-485759
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485759