The Role of the Intraplaque Vitamin D System in Atherogenesis
Joint Authors
Montecucco, Fabrizio
Carbone, Federico
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-26
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Diseases
Abstract EN
Vitamin D has been shown to play critical activities in several physiological pathways not involving the calcium/phosphorus homeostasis.
The ubiquitous distribution of the vitamin D receptor that is expressed in a variety of human and mouse tissues has strongly supported research on these “nonclassical” activities of vitamin D.
On the other hand, the recent discovery of the expression also for vitamin D-related enzymes (such as 25-hydroxyvitamin D-1α-hydroxylase and the catabolic enzyme 1,25-dihydroxyvitamin D-24-hydroxylase) in several tissues suggested that the vitamin D system is more complex than previously shown and it may act within tissues through autocrine and paracrine pathways.
This updated model of vitamin D axis within peripheral tissues has been particularly investigated in atherosclerotic pathophysiology.
This review aims at updating the role of the local vitamin D within atherosclerotic plaques, providing an overview of both intracellular mechanisms and cell-to-cell interactions.
In addition, clinical findings about the potential causal relationship between vitamin D deficiency and atherogenesis will be analysed and discussed.
American Psychological Association (APA)
Carbone, Federico& Montecucco, Fabrizio. 2013. The Role of the Intraplaque Vitamin D System in Atherogenesis. Scientifica،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-485767
Modern Language Association (MLA)
Carbone, Federico& Montecucco, Fabrizio. The Role of the Intraplaque Vitamin D System in Atherogenesis. Scientifica No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-485767
American Medical Association (AMA)
Carbone, Federico& Montecucco, Fabrizio. The Role of the Intraplaque Vitamin D System in Atherogenesis. Scientifica. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-485767
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485767