Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer
Joint Authors
Rutherford, Thomas
Yang, Yang
Holmberg, Jennie C.
Alvero, Ayesha B.
Hui, Pei
Silasi, Dan-Arin
Waldstrøm, Marianne
Mor, Gil
Jakobsen, Anders
Steffensen, Karina Dahl
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-08-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Epithelial ovarian cancer stem cells (EOC stem cells) have been associated with recurrence and chemoresistance.
CD44 and CK18 are highly expressed in cancer stem cells and function as tools for their identification and characterization.
We investigated the association between the number of CD44+ EOC stem cells in ovarian cancer tumors and progression-free survival.
EOC stem cells exist as clusters located close to the stroma forming the cancer stem cell “niche”.
17.1% of the samples reveled high number of CD44+ EOC stem cells (>20% positive cells).
In addition, the number of CD44+ EOC stem cells was significantly higher in patients with early-stage ovarian cancer (FIGO I/II), and it was associated with shorter progression-free survival (P=0.026).
This study suggests that quantification of the number of EOC stem cells in the tumor can be used as a predictor of disease and could be applied for treatment selection in early-stage ovarian cancer.
American Psychological Association (APA)
Steffensen, Karina Dahl& Alvero, Ayesha B.& Yang, Yang& Waldstrøm, Marianne& Hui, Pei& Holmberg, Jennie C.…[et al.]. 2011. Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer. Journal of Oncology،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-485770
Modern Language Association (MLA)
Steffensen, Karina Dahl…[et al.]. Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer. Journal of Oncology No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-485770
American Medical Association (AMA)
Steffensen, Karina Dahl& Alvero, Ayesha B.& Yang, Yang& Waldstrøm, Marianne& Hui, Pei& Holmberg, Jennie C.…[et al.]. Prevalence of Epithelial Ovarian Cancer Stem Cells Correlates with Recurrence in Early-Stage Ovarian Cancer. Journal of Oncology. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-485770
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485770
