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Molecular Characteristics of Pancreatic Ductal Adenocarcinoma
Joint Authors
Ottenhof, Niki A.
de Wilde, Roeland F.
Hruban, Ralph H.
Offerhaus, G. Johan A.
Maitra, Anirban
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-27
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Pancreatic cancer is an almost universally lethal disease and despite extensive research over the last decades, this has not changed significantly.
Nevertheless, much progress has been made in understanding the pathogenesis of pancreatic ductal adenocarcinoma (PDAC) suggesting that different therapeutic strategies based on these new insights are forthcoming.
Increasing focus exists on designing the so-called targeted treatment strategies in which the genetic characteristics of a tumor guide therapy.
In the past, the focus of research was on identifying the most frequently affected genes in PDAC, but with the complete sequencing of the pancreatic cancer genome the focus has shifted to defining the biological function that the altered genes play.
In this paper we aimed to put the genetic alterations present in pancreatic cancer in the context of their role in signaling pathways.
In addition, this paper provides an update of the recent advances made in the development of the targeted treatment approach in PDAC.
American Psychological Association (APA)
Ottenhof, Niki A.& de Wilde, Roeland F.& Maitra, Anirban& Hruban, Ralph H.& Offerhaus, G. Johan A.. 2011. Molecular Characteristics of Pancreatic Ductal Adenocarcinoma. Pathology Research International،Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-485774
Modern Language Association (MLA)
Ottenhof, Niki A.…[et al.]. Molecular Characteristics of Pancreatic Ductal Adenocarcinoma. Pathology Research International No. 2011 (2011), pp.1-16.
https://search.emarefa.net/detail/BIM-485774
American Medical Association (AMA)
Ottenhof, Niki A.& de Wilde, Roeland F.& Maitra, Anirban& Hruban, Ralph H.& Offerhaus, G. Johan A.. Molecular Characteristics of Pancreatic Ductal Adenocarcinoma. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-16.
https://search.emarefa.net/detail/BIM-485774
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485774