Temperature-Responsive Gelation of Type I Collagen Solutions Involving Fibril Formation and Genipin Crosslinking as a Potential Injectable Hydrogel
Joint Authors
Yunoki, Shunji
Hatayama, Hirosuke
Ohyabu, Yoshimi
Source
International Journal of Biomaterials
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-10-05
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
We investigated the temperature-responsive gelation of collagen/genipin solutions using pepsin-solubilized collagen (PSC) and acid-solubilized collagen (ASC) as substrates.
Gelation occurred in the PSC/genipin solutions at genipin concentrations 0–2 mM under moderate change in temperature from 25 to 37°C.
The PSC/genipin solutions exhibited fluidity at room temperature for at least 30 min, whereas the ASC/genipin solutions rapidly reached gel points.
In specific cases PSC would be preferred over ASC as an injectable gel system.
The temperature-responsive gelation of PSC/genipin solutions was due to temperature responses to genipin crosslinking and collagen fibril formation.
The elastic modulus of the 0.5% PSC/genipin gel system could be adjusted in a range of 2.5 to 50 kPa by the PSC and genipin concentrations, suggesting that a PSC/genipin solution is a potential injectable gel system for drug and cell carriers, with mechanical properties matching those of living tissues.
American Psychological Association (APA)
Yunoki, Shunji& Ohyabu, Yoshimi& Hatayama, Hirosuke. 2013. Temperature-Responsive Gelation of Type I Collagen Solutions Involving Fibril Formation and Genipin Crosslinking as a Potential Injectable Hydrogel. International Journal of Biomaterials،Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-485791
Modern Language Association (MLA)
Yunoki, Shunji…[et al.]. Temperature-Responsive Gelation of Type I Collagen Solutions Involving Fibril Formation and Genipin Crosslinking as a Potential Injectable Hydrogel. International Journal of Biomaterials No. 2013 (2013), pp.1-14.
https://search.emarefa.net/detail/BIM-485791
American Medical Association (AMA)
Yunoki, Shunji& Ohyabu, Yoshimi& Hatayama, Hirosuke. Temperature-Responsive Gelation of Type I Collagen Solutions Involving Fibril Formation and Genipin Crosslinking as a Potential Injectable Hydrogel. International Journal of Biomaterials. 2013. Vol. 2013, no. 2013, pp.1-14.
https://search.emarefa.net/detail/BIM-485791
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485791