![](/images/graphics-bg.png)
Oral Microencapsulated Live Saccharomyces cerevisiae Cells for Use in Renal Failure Uremia : Preparation and In Vivo Analysis
Joint Authors
Coussa, Razek
Prakash, Satya
Bhathena, Jasmine
Martoni, Christopher
Urbanska, Aleksandra Malgorzata
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-07-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Orally administrable alginate-poly-L-lysine-alginate (APA) microcapsules containing live yeast cells was investigated for use in renal failure.
At all times, yeast cells remain inside the microcapsules, which are then excreted in the stool.
During their gastrointestinal passage, small molecules, like urea, diffuse into the yeast microcapsules where they are hydrolyzed.
Orally administrating these microcapsules to uremic rats was found to decrease urea concentrations from 7.29±0.89 mmol/L to 6.12±0.90 mmol/L over a treatment period of eight weeks.
After stopping the treatment, the urea concentrations increased back to uremic levels of 7.64±0.77 mmol/L.
The analysis of creatinine concentrations averaged 39.19±4.33 μmol/L, 50.83±5.55 μmol/L, and 50.28±7.10 μmol/L for the normal-control, uremic-control and uremic-treatment groups, respectively.
While creatinine concentrations for both uremic-control and uremic-treatment groups did not differ among each other (P>.05), they were, however, significantly higher than those of the normal control group (P<.05).
Uric acid concentrations averaged 80.08±26.49 μmol/L, 99.92±26.55 μmol/L, and 86.49±28.42 μmol/L for the normal-control, uremic-control and uremic-treatment groups, respectively.
There were no significant differences in both calcium and phosphate concentrations among all three groups (P>.05).
The microbial populations of five tested types of bacteria were not substantially altered by the presence of the yeast APA encapsulated yeast (P>.05).
American Psychological Association (APA)
Coussa, Razek& Martoni, Christopher& Bhathena, Jasmine& Urbanska, Aleksandra Malgorzata& Prakash, Satya. 2010. Oral Microencapsulated Live Saccharomyces cerevisiae Cells for Use in Renal Failure Uremia : Preparation and In Vivo Analysis. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485795
Modern Language Association (MLA)
Coussa, Razek…[et al.]. Oral Microencapsulated Live Saccharomyces cerevisiae Cells for Use in Renal Failure Uremia : Preparation and In Vivo Analysis. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-7.
https://search.emarefa.net/detail/BIM-485795
American Medical Association (AMA)
Coussa, Razek& Martoni, Christopher& Bhathena, Jasmine& Urbanska, Aleksandra Malgorzata& Prakash, Satya. Oral Microencapsulated Live Saccharomyces cerevisiae Cells for Use in Renal Failure Uremia : Preparation and In Vivo Analysis. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-7.
https://search.emarefa.net/detail/BIM-485795
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485795