PPARγ in Inflammatory Bowel Disease
Joint Authors
Rogai, Francesca
Settesoldi, Alessia
Bagnoli, Siro
Annese, Vito
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-10
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Peroxisome proliferator-activated receptor gamma (PPARγ) is member of a family of nuclear receptors that interacts with nuclear proteins acting as coactivators and corepressors.
The colon is a major tissue which expresses PPARγ in epithelial cells and, to a lesser degree, in macrophages and lymphocytes and plays a role in the regulation of intestinal inflammation.
Indeed, both natural and synthetic PPARγ ligands have beneficial effects in different models of experimental colitis, with possible implication in the therapy of inflammatory bowel disease (IBD).
This paper will specifically focus on potential role of PPARγ in the predisposition and physiopathology of IBD and will analyze its possible role in medical therapy.
American Psychological Association (APA)
Annese, Vito& Rogai, Francesca& Settesoldi, Alessia& Bagnoli, Siro. 2012. PPARγ in Inflammatory Bowel Disease. PPAR Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-485799
Modern Language Association (MLA)
Annese, Vito…[et al.]. PPARγ in Inflammatory Bowel Disease. PPAR Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-485799
American Medical Association (AMA)
Annese, Vito& Rogai, Francesca& Settesoldi, Alessia& Bagnoli, Siro. PPARγ in Inflammatory Bowel Disease. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-485799
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485799