Muscle-Based Pharmacokinetic Modeling of Marrow Perfusion for Osteoporotic Bone in Females
Joint Authors
Leung, Ping-Chung
Griffth, James F.
Ma, Heather Ting
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The pharmacokinetic model has been widely used in tissue perfusion analysis, such as bone marrow perfusion.
In the modeling process, the arterial input function is important to guarantee the reliability of the fitting result.
However, the arterial input function is variable and hard to control, which makes it difficult to compare results across different studies.
The purpose of this study was to establish a muscle-based pharmacokinetic model for bone marrow perfusion without using arterial input function.
Erector spinae muscle around the vertebral body was selected as the reference region.
The study was carried out in elderly females with different bone mineral densities (normal, osteopenia, and osteoporosis).
Quantitative parameters were extracted from the pharmacokinetic model.
Parameter Ktrans,BM (contrast agent extravasation rate constants for blood perfusion of the bone marrow) showed a significant reduction in subjects with lower bone mineral density, which is consistent with previous studies.
However, muscle perfusion parameters remained unchanged among different groups.
The results indicated that the muscle-based model was stable for bone marrow perfusion modeling.
Additionally, nonsignificant change in muscle parameters indicated that the diminished perfusion is only a local rather than a systematic change in the bone marrow for osteoporosis.
American Psychological Association (APA)
Ma, Heather Ting& Griffth, James F.& Leung, Ping-Chung. 2014. Muscle-Based Pharmacokinetic Modeling of Marrow Perfusion for Osteoporotic Bone in Females. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-485805
Modern Language Association (MLA)
Ma, Heather Ting…[et al.]. Muscle-Based Pharmacokinetic Modeling of Marrow Perfusion for Osteoporotic Bone in Females. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-485805
American Medical Association (AMA)
Ma, Heather Ting& Griffth, James F.& Leung, Ping-Chung. Muscle-Based Pharmacokinetic Modeling of Marrow Perfusion for Osteoporotic Bone in Females. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-485805
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485805