Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice : A Role for PPARα
Joint Authors
MacLean, Paul
Knoch, Bianca
Zhu, Shuotun
Knowles, Scott O.
Barnett, Matthew P. G.
Park, Zaneta A.
Cooney, Janine
Barraclough, Diane
Roy, Nicole C.
McNabb, Warren C.
Laing, William
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-30
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The interleukin-10 gene-deficient (Il10-/-) mouse is a model of human inflammatory bowel disease and Ppara has been identified as one of the key genes involved in regulation of colitis in the bacterially inoculated Il10-/- model.
The aims were to (1) characterize colitis onset and progression using a histopathological, transcriptomic, and proteomic approach and (2) investigate links between PPARα and IL10 using gene network analysis.
Bacterial inoculation resulted in severe colitis in Il10-/- mice from 10 to 12 weeks of age.
Innate and adaptive immune responses showed differences in gene expression relating to colitis severity.
Actin cytoskeleton dynamics, innate immunity, and apoptosis-linked gene and protein expression data suggested a delayed remodeling process in 12-week-old Il10-/- mice.
Gene expression changes in 12-week-old Il10-/- mice were related to PPARα signaling likely to control colitis, but how PPARα activation might regulate intestinal IL10 production remains to be determined.
American Psychological Association (APA)
Knoch, Bianca& Barnett, Matthew P. G.& Cooney, Janine& McNabb, Warren C.& Barraclough, Diane& Laing, William…[et al.]. 2010. Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice : A Role for PPARα. PPAR Research،Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-485823
Modern Language Association (MLA)
Knoch, Bianca…[et al.]. Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice : A Role for PPARα. PPAR Research No. 2010 (2010), pp.1-18.
https://search.emarefa.net/detail/BIM-485823
American Medical Association (AMA)
Knoch, Bianca& Barnett, Matthew P. G.& Cooney, Janine& McNabb, Warren C.& Barraclough, Diane& Laing, William…[et al.]. Molecular Characterization of the Onset and Progression of Colitis in Inoculated Interleukin-10 Gene-Deficient Mice : A Role for PPARα. PPAR Research. 2010. Vol. 2010, no. 2010, pp.1-18.
https://search.emarefa.net/detail/BIM-485823
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485823