Circulating Tumor Cells in Breast Cancer Patients : An Evolving Role in Patient Prognosis and Disease Progression
Joint Authors
Graves, Holly
Czerniecki, Brian J.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
In this paper, we examine the role of circulating tumor cells (CTCs) in breast cancer.
CTCs are tumor cells present in the peripheral blood.
They are found in many different carcinomas but are not present in patients with benign disease.
Recent advances in theories regarding metastasis support the role of early release of tumor cells in the neoplastic process.
Furthermore, it has been found that phenotypic variation exists between the primary tumor and CTCs.
Of particular interest is the incongruency found between primary tumor and CTC HER2 status in both metastatic and early breast cancer.
Overall, CTCs have been shown to be a poor prognostic marker in metastatic breast cancer.
CTCs in early breast cancer are not as well studied, however, several studies suggest that the presence of CTCs in early breast cancer may also suggest a poorer prognosis.
Studies are currently underway looking at the use of CTC level monitoring in order to guide changes in therapy.
American Psychological Association (APA)
Graves, Holly& Czerniecki, Brian J.. 2011. Circulating Tumor Cells in Breast Cancer Patients : An Evolving Role in Patient Prognosis and Disease Progression. Pathology Research International،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-485827
Modern Language Association (MLA)
Graves, Holly& Czerniecki, Brian J.. Circulating Tumor Cells in Breast Cancer Patients : An Evolving Role in Patient Prognosis and Disease Progression. Pathology Research International No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-485827
American Medical Association (AMA)
Graves, Holly& Czerniecki, Brian J.. Circulating Tumor Cells in Breast Cancer Patients : An Evolving Role in Patient Prognosis and Disease Progression. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-485827
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485827