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Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells
Joint Authors
Wang, Tao
Dai, Hanren
Han, Weidong
Lv, Haiyan
Wang, Yao
Li, Hong
Fu, Xiaobing
Source
Clinical and Developmental Immunology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-01
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Previous reports have suggested that treatment with cytokine-induced killer (CIK) cells may benefit patients with various types of tumor.
The aim of this study was to evaluate the antitumor effects of CIK cells against the colorectal cancer line SW1116 in vitro and in vivo.
CIK cells were generated routinely from peripheral blood mononuclear cells of healthy human donors, and the number of CD3+CD56+ cells was expanded more than 1300-fold after 14-day culture.
At an effector : target cell ratio of 50 : 1, the percentage lysis of SW1116 cells reached 68% in the presence of CIK cells, Experimental mice injected with SW1116 cells subcutaneously were divided randomly into four groups: untreated, 5-fluorouracil (5-FU)-treated, CIK-consecutive treated (injected once/day) and CIK-interval treated (injected once every 5 days).
CIK cells were injected abdominally five times in total.
Compared with the untreated group, xenograft growth was inhibited greatly by CIK treatment, to nearly the same extent as with 5-FU treatment.
We demonstrated that the necrotic area in the tumor xenograft was markedly larger in the CIK-treated groups than in the other groups.
These findings suggest that CIK-based immunotherapy may represent an effective choice for patients with colorectal cancer.
American Psychological Association (APA)
Wang, Yao& Dai, Hanren& Li, Hong& Lv, Haiyan& Wang, Tao& Fu, Xiaobing…[et al.]. 2010. Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells. Clinical and Developmental Immunology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485853
Modern Language Association (MLA)
Wang, Yao…[et al.]. Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells. Clinical and Developmental Immunology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485853
American Medical Association (AMA)
Wang, Yao& Dai, Hanren& Li, Hong& Lv, Haiyan& Wang, Tao& Fu, Xiaobing…[et al.]. Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells. Clinical and Developmental Immunology. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485853
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485853