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Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia
Joint Authors
Avvisati, G.
Marchesi, F.
Girardi, K.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Translocation t(4;11)(q21;q23) leading to formation of MLL-AF4 fusion gene is found in about 10% of newly diagnosed B-cell acute lymphoblastic leukemia (ALL) in adult patients.
Patients expressing this chromosomal aberration present typical biological, immunophenotypic, and clinical features.
This form of leukemia is universally recognized as high-risk leukemia and treatment intensification with allogeneic hematopoietic stem cell transplantation (HSCT) in first complete remission (CR) could be a valid option to improve prognosis, but data obtained from the literature are controversial.
In this review, we briefly describe pathogenetic, clinical, and prognostic characteristics of adult t(4;11)(q21;q23)/MLL-AF4 positive ALL and provide a review of the clinical outcome reported by the most important cooperative groups worldwide.
American Psychological Association (APA)
Marchesi, F.& Girardi, K.& Avvisati, G.. 2011. Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia. Advances in Hematology،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-485876
Modern Language Association (MLA)
Marchesi, F.…[et al.]. Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia. Advances in Hematology No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-485876
American Medical Association (AMA)
Marchesi, F.& Girardi, K.& Avvisati, G.. Pathogenetic, Clinical, and Prognostic Features of Adult t(4;11)(q21;q23)MLL-AF4 Positive B-Cell Acute Lymphoblastic Leukemia. Advances in Hematology. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-485876
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485876