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Inhibition of Klebsiella pneumoniae Growth and Capsular Polysaccharide Biosynthesis by Fructus mume
Joint Authors
Jinn, Tzyy-Rong
Liu, Hsin-Ho
Lin, Ching-Ting
Chen, Yeh
Huang, Su-Hua
Lin, Tien-Huang
Wu, Chien-Chen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Klebsiella pneumoniae is the predominant pathogen isolated from liver abscess of diabetic patients in Asian countries.
With the spread of multiple-drug-resistant K.
pneumoniae, there is an increasing need for the development of alternative bactericides and approaches to block the production of bacterial virulence factors.
Capsular polysaccharide (CPS), especially from the K1 and K2 serotypes, is considered the major determinant for K.
pneumoniae virulence.
We found that extracts of the traditional Chinese medicine Fructus mume inhibited the growth of K.
pneumoniae strains of both serotypes.
Furthermore, Fructus mume decreased the mucoviscosity, and the CPS produced in a dose-dependent manner, thus reducing bacterial resistance to serum killing.
Quantitative reverse transcription polymerase chain reaction analyses showed that Fructus mume downregulated the mRNA levels of cps biosynthesis genes in both serotypes, possibly by increasing the intracellular iron concentration in K.
pneumoniae.
Moreover, citric acid, a major organic acid in Fructus mume extracts, was found to have an inhibitory effect on growth and CPS biosynthesis in K.
pneumoniae.
Taken together, our results indicate that Fructus mume not only possesses antibacterial activity against highly virulent K.
pneumoniae strains but also inhibits bacterial CPS biosynthesis, thereby facilitating pathogen clearance by the host immune system.
American Psychological Association (APA)
Lin, Tien-Huang& Huang, Su-Hua& Wu, Chien-Chen& Liu, Hsin-Ho& Jinn, Tzyy-Rong& Chen, Yeh…[et al.]. 2013. Inhibition of Klebsiella pneumoniae Growth and Capsular Polysaccharide Biosynthesis by Fructus mume. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-485888
Modern Language Association (MLA)
Lin, Tien-Huang…[et al.]. Inhibition of Klebsiella pneumoniae Growth and Capsular Polysaccharide Biosynthesis by Fructus mume. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-485888
American Medical Association (AMA)
Lin, Tien-Huang& Huang, Su-Hua& Wu, Chien-Chen& Liu, Hsin-Ho& Jinn, Tzyy-Rong& Chen, Yeh…[et al.]. Inhibition of Klebsiella pneumoniae Growth and Capsular Polysaccharide Biosynthesis by Fructus mume. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-485888
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485888