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Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy
Joint Authors
Soda, Elizabeth
Kinzie, Kay
Forster-Harwood, Jeri
Salbenblatt, Carol
Davies, Jill
McFarland, Elizabeth J.
Barr, Emily
Vazquez, Anna
Pappas, Jennifer
Peloquin, Charles A.
Levin, Myron J.
Paul, Suzanne
Weinberg, Adriana
Source
Infectious Diseases in Obstetrics and Gynecology
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-01-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
HIV-infected pregnant women with undetectable plasma HIV RNA concentrations at delivery pose a minimal risk of vertical transmission.
We studied the kinetics and the determinants of the virologic response to antiretroviral therapy in 117 consecutive pregnancies.
Patients who initiated therapy during pregnancy had a VL decrease of 2 and 2.5 log10 after 4 and 24 weeks, respectively.
Therapeutic drug monitoring (TDM) of the protease inhibitors administered in doses recommended for nonpregnant adults resulted in below-target concentrations in 29%, 35%, and 44% of 1st, 2nd, and 3rd trimester measurements, respectively, but low drug concentrations did not correlate with virologic failure.
Demographic characteristics, antiretroviral experience prior to pregnancy, baseline VL, or use of specific antiretrovirals did not affect the virologic response.
Adherence to ≥95% of prescribed doses and utilization of psychosocial services were associated with undetectable plasma HIV RNA at delivery.
In conclusion, the virologic responses of pregnant and nonpregnant adults share similar charactersitics.
American Psychological Association (APA)
Weinberg, Adriana& Forster-Harwood, Jeri& McFarland, Elizabeth J.& Pappas, Jennifer& Davies, Jill& Kinzie, Kay…[et al.]. 2010. Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy. Infectious Diseases in Obstetrics and Gynecology،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-485890
Modern Language Association (MLA)
Weinberg, Adriana…[et al.]. Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy. Infectious Diseases in Obstetrics and Gynecology No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-485890
American Medical Association (AMA)
Weinberg, Adriana& Forster-Harwood, Jeri& McFarland, Elizabeth J.& Pappas, Jennifer& Davies, Jill& Kinzie, Kay…[et al.]. Kinetics and Determining Factors of the Virologic Response to Antiretrovirals during Pregnancy. Infectious Diseases in Obstetrics and Gynecology. 2010. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-485890
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485890