Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease
Joint Authors
Petragallo, Vito A.
Bobba, Antonella
Marra, Ersilia
Atlante, Anna
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-09-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this paper, we discuss the interplay between beta-amyloid (Aβ) peptide, Tau fragments, oxidative stress, and mitochondria in the neuronal model of cerebellar granule neurons (CGNs) in which the molecular events reminiscent of AD are activated.
The identification of the death route and the cause/effect relationships between the events leading to death could be helpful to manage the progression of apoptosis in neurodegeneration and to define antiapoptotic treatments acting on precocious steps of the death process.
Mitochondrial dysfunction is among the earliest events linked to AD and might play a causative role in disease onset and progression.
Recent studies on CGNs have shown that adenine nucleotide translocator (ANT) impairment, due to interaction with toxic N-ter Tau fragment, contributes in a significant manner to bioenergetic failure and mitochondrial dysfunction.
These findings open a window for new therapeutic strategies aimed at preserving and/or improving mitochondrial function.
American Psychological Association (APA)
Bobba, Antonella& Petragallo, Vito A.& Marra, Ersilia& Atlante, Anna. 2010. Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-485898
Modern Language Association (MLA)
Bobba, Antonella…[et al.]. Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2010 (2010), pp.1-11.
https://search.emarefa.net/detail/BIM-485898
American Medical Association (AMA)
Bobba, Antonella& Petragallo, Vito A.& Marra, Ersilia& Atlante, Anna. Alzheimer's Proteins, Oxidative Stress, and Mitochondrial Dysfunction Interplay in a Neuronal Model of Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2010, no. 2010, pp.1-11.
https://search.emarefa.net/detail/BIM-485898
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485898