Germ Cell Proteins in Melanoma : Prognosis, Diagnosis, Treatment, and Theories on Expression
Joint Authors
Dabas, Nitika
Eller, Mark S.
Grichnik, James M.
Rosa, Ashley M.
Byrnes, Diana M.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Germ cell protein expression in melanoma has been shown to correlate with malignancy, severity of disease and to serve as an immunologic target for therapy.
However, very little is known about the role that germ cell proteins play in cancer development.
Unique germ cell pathways include those involved in immortalization, genetic evolution, and energy metabolism.
There is an ever increasing recognition that within tumors there is a subpopulation of cells with stem-cell-like characteristics that play a role in driving tumorgenesis.
Stem cell and germ cell biology is intertwined.
Given the enormous potential and known expression of germ cell proteins in melanoma, it is possible that they represent a largely untapped resource that may play a fundamental role in tumor development and progression.
The purpose of this paper is to provide an update on the current value of germ cell protein expression in melanoma diagnosis, prognosis, and therapy, as well as to review critical germ cell pathways and discuss the potential roles these pathways may play in malignant transformation.
American Psychological Association (APA)
Rosa, Ashley M.& Dabas, Nitika& Byrnes, Diana M.& Eller, Mark S.& Grichnik, James M.. 2012. Germ Cell Proteins in Melanoma : Prognosis, Diagnosis, Treatment, and Theories on Expression. Journal of Skin Cancer،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485913
Modern Language Association (MLA)
Rosa, Ashley M.…[et al.]. Germ Cell Proteins in Melanoma : Prognosis, Diagnosis, Treatment, and Theories on Expression. Journal of Skin Cancer No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-485913
American Medical Association (AMA)
Rosa, Ashley M.& Dabas, Nitika& Byrnes, Diana M.& Eller, Mark S.& Grichnik, James M.. Germ Cell Proteins in Melanoma : Prognosis, Diagnosis, Treatment, and Theories on Expression. Journal of Skin Cancer. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-485913
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485913