Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease
Joint Authors
DeToma, Alaina S.
Choi, Jung-Suk
Braymer, Joseph J.
Ko, Kristin S.
Lim, Mi Hee
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-12-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Alzheimer's disease (AD) is a multifactorial neurodegenerative disease related to the deposition of aggregated amyloid-β (Aβ) peptides in the brain.
It has been proposed that metal ion dyshomeostasis and miscompartmentalization contribute to AD progression, especially as metal ions (e.g., Cu(II) and Zn(II)) found in Aβ plaques of the diseased brain can bind to Aβ and be linked to aggregation and neurotoxicity.
The role of metal ions in AD pathogenesis, however, is uncertain.
To accelerate understanding in this area and contribute to therapeutic development, recent efforts to devise suitable chemical reagents that can target metal ions associated with Aβ have been made using rational structure-based design that combines two functions (metal chelation and Aβ interaction) in the same molecule.
This paper presents bifunctional compounds developed by two different design strategies (linkage or incorporation) and discusses progress in their applications as chemical tools and/or potential therapeutics.
American Psychological Association (APA)
Braymer, Joseph J.& DeToma, Alaina S.& Choi, Jung-Suk& Ko, Kristin S.& Lim, Mi Hee. 2010. Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485922
Modern Language Association (MLA)
Braymer, Joseph J.…[et al.]. Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-485922
American Medical Association (AMA)
Braymer, Joseph J.& DeToma, Alaina S.& Choi, Jung-Suk& Ko, Kristin S.& Lim, Mi Hee. Recent Development of Bifunctional Small Molecules to Study Metal-Amyloid-β Species in Alzheimer's Disease. International Journal of Alzheimer's Disease. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-485922
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-485922